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Huntington's Disease (HD) treatment challenges due to genetic complexity.

Researchers focus on cellular messaging within the HD brain.

Thiamine/biotin connection discovered in HD biochemical juncture.

HD linked to extra DNA triplet copies in the Htt gene.

Effects of HD arise from mRNA repeats and polyQ aberrations.

CPEBs genes identified for their role in HD gene abnormalities.

Clinical trial underway to test high thiamine and biotin doses.

Safety and tolerability of thiamine and biotin being assessed.

Importance of patients not self-administering thiamine and biotin.

Potential for larger trials based on pilot study results.